Current Expert Opinion and Literature Review
on Metastatic Colorectal Cancer in Latin America 

Colorectal cancer (CRC) is the second leading cause of death in Latin America and is projected to increase by 65.4% by 2040. An activating BRAF mutation is found in up to 15% of metastatic CRC cases in Latin America.

Targeted therapies for BRAF-V600E mutated metastatic colorectal cancer have been shown to improve outcomes for patients in clinical trials. However, BRAF-V600E testing and the management of positive cases are inconsistent across Latin America

In November 2022, AHF convened a meeting of Latin American experts on BRAF-V600E metastatic colorectal cancer to develop recommendations for managing the disease. The manuscript entitled “Current BRAF-V600E CRC management landscape in LATAM: An expert LATAM panel recommendations” is under review for publication.

Lead author: Anelisa Coutinho